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Updated: Aug 18, 2026
Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
Published on: December 10, 2012
The putative melanoma tumor-suppressor gene on human chromosome 6q
1Department of Oncology, Royal Alexandra Hospital for Children, Camperdown, NSW.
Abstract:
The tumorigenicity of malignant melanoma cells may be suppressed experimentally by the introduction into these cells of human chromosome 6 or mouse chromosome 4. These chromosomes share a homologous region, contained in human chromosome 6q12-21. Abnormalities of this human chromosomal region have been found frequently not only in cutaneous and uveal malignant melanomas, but also in a range of other tumors. In all these, mutations of tumor-suppressor genes on human chromosome 6q may be involved. Identification of this putative tumor-suppressor gene may give new insights into the biology of malignant melanomas, and could pave the way for new treatment for such tumors, based upon the tumor-suppressor protein which this gene is likely to encode.
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