Related Experiment Videos
Desensitization to DNFB in hairless mice.
1Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia.
Contact Dermatitis
|September 1, 1987
Summary
New research shows ultraviolet B (UVB) light can induce partial tolerance to dinitrofluorobenzene (DNFB) in naive mice. However, this UVB treatment does not reduce established hypersensitivity in previously sensitized mice.
Area of Science:
- Immunology
- Dermatology
- Photobiology
Background:
- Dinitrofluorobenzene (DNFB) is a common contact sensitizer.
- Ultraviolet B (UVB) radiation can modulate immune responses.
- Inducing tolerance to allergens is a key goal in immunology.
Purpose of the Study:
- To investigate if UVB irradiation can induce tolerance to DNFB in naive mice.
- To determine if UVB irradiation can reduce established DNFB hypersensitivity.
Main Methods:
- Hairless mice were painted with DNFB on skin irradiated with 30 mJ.cm-2 UVB over 4 days.
- Sensitized mice were repainted with DNFB on UVB-irradiated skin.
Main Results:
- Naive mice showed partial tolerance to DNFB after UVB treatment.
- Established DNFB hypersensitivity in sensitized mice was not reduced by UVB treatment.
Conclusions:
- UVB irradiation can induce a degree of tolerance in naive skin.
- This UVB-induced tolerance strategy is ineffective for reducing existing contact hypersensitivity.