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Synthesis and interaction studies of watersoluble nucleic acid analogs containing serine as a spacer
T Wada1, N Masumi, E Mochizuki
1Faculty of Engineering, Osaka University, Japan.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
Watersoluble nucleic acid analogs containing L- or D-serine as a spacer were synthesized. Thymine was used as nucleic acid bases of these analogs. The base contents of these analogs were 93-94%. These analogs were found to form stable polymer complexes with Poly A or DNA by specific base-base interaction, which were observed from hypochromicity of UV spectra. In both cases, the maximum hypochromicity values of PEI-L-Ser-Thy were higher than that of PEI-D-Ser-Thy.