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Synthesis and property of alpha-oligodeoxynucleotide phosphorothioate
K Shinozuka1, Y Hirota, T Morita
1Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu City, Japan.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
Unnatural DNA analog, alpha-2'-deoxy-oligoadenylate phosphorothioate bearing 3'-normal monophosphate moiety was conveniently synthesized through phosphoramidite solid support method. The starting material of the DNA analog, alpha-2'-deoxyadenosine, was prepared in a stereospecific manner by the coupling reaction between activated nucleobase and 1-chloro-2-deoxyribose derivative.