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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Hepatitis C virus seroprevalence rate among Saudis
Ossama A Shobokshi1, Frank E Serebour, Abdullah Z Al-Drees
1King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Insights
Hepatitis C virus (HCV) seroprevalence in Saudi Arabia is low in the general population but high in at-risk groups. Public health efforts reduced community spread, yet challenges remain for hemodialysis patients and drug addicts.
Area of Science:
- Hepatology
- Virology
- Public Health
Background:
- Hepatitis C virus (HCV) infection poses a significant global health challenge.
- Understanding regional seroprevalence is crucial for targeted public health interventions.
Purpose of the Study:
- To determine the seroprevalence of Hepatitis C Virus (HCV) in various Saudi Arabian populations.
- To assess HCV infection rates in blood donors, children, pregnant women, hemodialysis patients, and drug addicts.
Main Methods:
- Utilized third-generation enzyme immunoassay kits for antibody screening.
- Screened diverse Saudi cohorts including infants, children, young adults, and adults.
- Reviewed existing HCV seroprevalence data for high-risk groups from 1998-2002.
Main Results:
- Overall HCV seroprevalence was 1.1% in blood donors and 0.1% in children.
- Seroprevalence was 0.7% in pregnant women, but significantly higher in high-risk groups.
- Hemodialysis patients showed a 55.7% infection rate, and intravenous drug users had a 14% exposure rate.
Conclusions:
- Current public health initiatives have successfully reduced HCV in the general Saudi community.
- HCV remains a significant concern among high-risk populations, necessitating focused interventions.
- Continued monitoring and targeted strategies are essential to control HCV in Saudi Arabia.
Objective:
The aim of the study is to determine the seroprevalence of hepatitis C virus (HCV) in blood donors, children, pregnant women, hemodialysis patients and drug addicts in Saudi Arabia.
Methods:
Using third generation enzyme immunoassay kits, we have screened Saudi cohorts of all ages and sexes, namely infants, pre-school, school children, young adults and adults (blood donors and antenatals) for antibodies to HCV. We have also reviewed HCV seroprevalence data among high risk groups from 1998 to 2002.
Results:
An overall 1.1% (6313 out of 557813) seroprevalence rate was determined among Saudi blood donors; 0.1% (5 out of 3854) in Saudi children; and 0.7% (22 out of 3127) among pregnant women. Hemodialysis patients remain at highest risk of infection at 55.7% whereas intravenous drug addicts have 14% exposure rate.
Conclusion:
We conclude that the present public health schemes have been effective in reducing hepatitis C infection in the general community in the Kingdom of Saudi Arabia but the infection among high risk groups remain a major problem that needs to be actively addressed.
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