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Novel strategies towards construction of non-ionic and achiral backbones in antisense oligonucleotides
Y S Sanghvi1, J J Vasseur, F Debart
1Isis Pharmaceuticals, Carlsbad, CA 92008.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
A convenient synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-O-NCH3-CH2-4'-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 3'-deoxy-3'-C-hydroxymethyl-thymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides.