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Alkylation reaction of phosphorus oxyacids
H Ayukawa1, S Ohuchi, S Higashiya
1Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
Nucleic Acids Symposium Series
|January 1, 1992
Abstract:
Alkylation reactions of phosphorus oxyacids (i.e. phosphoric acid, phosphorous acid, hypophosphorous acid) were examined by means of several methods for the synthesis of the corresponding esters. These reactions were applied to the synthesis of oligonucleotide having phosphotriester bond or phosphonate diester bond.