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Interleukin-18 serum concentration in patients with psoriasis triggered by infection
Aldona Pietrzak1, Barbara Lecewicz-Toruń, Jacek Roliński
1Department of Dermatology, Department of Clinical Immunology, Medical University of Lublin.
Abstract:
The blood serum concentrations of IL-18 and the subpopulation of blood lymphocytes in peripheral blood were investigated in 14 patients with psoriasis preceded by a bacterial infection. The IL-18 concentrations were measured with the ELISA method, and the lymphocyte subpopulation--by flow cytometry. The elevated IL-18 concentrations in blood serum were observed; however, the increase was statistically insignificant in the group of psoriatic patients in comparison with the control (p > 0.4). The result of flow cytometry showed that a statistically significant increase of the percentage of CD45RO4 and CD45RO cells, and a statistically significant decrease of MFI expression of CD19+ and CD3+ cells (p < 0.004; p < 0.02; p < 0.05; p < 0.05) occurred in the patients.