Related Experiment Video
Updated: Sep 20, 2026

Post Column Derivatization Using Reaction Flow High Performance Liquid Chromatography Columns
Published on: April 26, 2016
Analytical solution of the ideal, nonlinear model of reaction chromatography for a reaction A-->B and a parabolic
Bingchang Lin1, Feng Song, Georges Guiochon
1Center of Separation Technology, Anshan University of Science and Technology, Anshan, Liaoning 114044, China.
Abstract:
The analytical solution of the ideal, nonlinear model of reaction chromatography for the simplest possible chemical reaction, A-->B and with a parabolic isotherm for the reagent, is derived for two types of boundary conditions, the injection of a rectangular concentration pulse of finite width (elution) and that of an instantaneous concentration jump (Riemann problem or breakthrough curve). The areas of the profiles of the reagent and of the product of the reaction are calculated in both the ideal and the nonideal cases. The effects of the nonlinear behavior of the equilibrium isotherm and of axial dispersion on the reagent profile are discussed using analytical and numerical methods.
Related Concept Videos
The Integrated Rate Law: The Dependence of Concentration on Time
Nonideal Two-Component Liquid Solutions
Le Chatelier's Principle: Changing Concentration
Column Efficiency: Rate Theory
During elution, a solute molecule experiences numerous transitions between stationary and mobile phases, exhibiting irregular residence times in...
Consecutive Reactions
Reaction Mechanisms: The Steady-State Approximation

