The pathogenesis of experimental model of mitochondrial myopathy induced by germanium dioxide
Objective:
The purpose of the study was to build up an animal model of mitochondrial myopathy in order to analyse the pathogenesis of the disease.
Methods:
The skeletal muscles from Wistar rats treated with germanium dioxide for 24 weeks were analysed by histopathologic and electron-microscopic studies. A quantitative analysis was carried out in mitochondrial DNAs of these samples. The biological function of the model was determined.
Results:
An animal model of mitochondrial myopathy was built up, in which oxygen free radicals were increased and mitochondrial DNA copies were decreased contrasted with controls.
Conclusion:
It suggested that environmental toxin may play a role in the pathogenesis of mitochondrial myopathy. The increase of oxygen free radicals is an important link causing the disease.
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