Related Experiment Video
Updated: Sep 20, 2026

In Vivo Microdialysis Method to Collect Large Extracellular Proteins from Brain Interstitial Fluid with High-molecular Weight Cut-off Probes
Published on: September 26, 2018
Utilization of in vivo ultrafiltration in biomedical research and clinical applications
Gea Leegsma-Vogt1, Elsa Janle, Stephen R Ash
1Department of Psychiatry, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. g.vogt@acggn.azg.nl
Abstract:
Ultrafiltration (UF) is a filtrate selection method with a wide range of biomedical and clinical applications, including detoxification of blood in hemodialysis and peritoneal dialysis. New is, however, the use of UF as a convenient in vivo sampling method that, for example, has been used in diabetics. Ultrafiltration avoids complicated and time-consuming recovery calculations that are necessary when using in vivo microdialysis, as recoveries of low molecular weight molecules are near 100%. The subcutaneously or intravenously placed UF probes have been studied for off-line sample analysis and for continuous on-line monitoring, in a wide variety of species, including dogs, rats, pigs and humans. This review discusses the potential of in vivo UF as a continuous tissue sampling technique in clinical research areas, and in several major biomedical applications including glucose and lactate monitoring and drug kinetic studies.
Related Concept Videos
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Dialysis
Filtration and Urine Formation
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Continuous Renal Replacement Therapy

