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Does neurofilament phosphorylation regulate axonal transport?
Thomas B Shea1, Cheolwha Jung, Harish C Pant
1Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA. thomas_shea@uml.edu
Trends in Neurosciences
|August 6, 2003
Abstract:
Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.