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What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?
Peter A Bretscher1, Duane Hamilton, Oladele Ogunremi
1Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada. bretschr@duke.usask.ca
Expert Review of Vaccines
|August 7, 2003
Abstract:
An appreciation of global features of immune regulation may lead to vaccination strategies effective in a genetically diverse population against a number of intracellular pathogens that cause chronic disease. Such global strategies appear more straightforward than strategies requiring a detailed knowledge of the specificity of 'protective T-cells'. Global strategies may be effective against the virus, bacteria and protozoa that respectively cause AIDS, tuberculosis and the leishmaniases.