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Thrombosis in spinal cord injury.

Y Fujii¹, E F Mammen, A Farag

¹Department of Neurosurgery, Niigata Brain Research Institute, Japan.

Thrombosis Research

|December 1, 1992

Summary

Spinal cord injury patients frequently develop deep vein thrombosis (DVT). Molecular markers like thrombin/antithrombin III complexes can indicate DVT risk before diagnosis.

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Area of Science:

Thrombosis and hemostasis research
Clinical investigation of spinal cord injury complications

Background:

Deep vein thrombosis (DVT) is a significant risk following spinal cord injury (SCI).
Understanding hemostatic activation markers in SCI patients is crucial for early DVT detection.

Purpose of the Study:

To evaluate traditional coagulation assays and novel molecular markers of hemostatic activation in SCI patients.
To determine the incidence and predictors of DVT in SCI.

Main Methods:

Measurement of coagulation assays and molecular markers in 37 SCI patients.
Diagnosis of DVT using the radiofibrinogen uptake test (RFUT).
Comparison of marker levels between patients with and without DVT.

Main Results:

DVT developed in 57% of SCI patients; incidence was higher in paraplegic (88%) vs. quadriplegic (38%) patients.
No significant differences in platelet counts or standard coagulation factors between DVT+ and DVT- groups.
Elevated Fibrinopeptide A, thrombin/antithrombin III (TAT) complexes, and D-dimer levels were associated with DVT.
TAT complexes were elevated up to 3 days prior to positive RFUT; D-dimer peaked post-diagnosis.

Conclusions:

Molecular markers, particularly TAT complexes, show promise for early DVT detection in SCI patients.
Standard coagulation tests are less effective in identifying DVT risk in this population.
Paraplegia is a significant risk factor for DVT development post-SCI.

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