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Interleukin-1 gene cluster polymorphisms in cerebral infarction.

Jae-Young Um1, Kyung-Suk Moon, Kang-Min Lee

  • 1Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea.

Cytokine
|August 7, 2003
PubMed
Summary

Interleukin-1 alpha (IL-1alpha) gene polymorphisms are linked to increased risk of cerebral infarction (CI). Specifically, IL-1alpha (-889) allele 2 carriers showed a higher prevalence and risk of CI in the Korean population.

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Interleukin-1 (IL-1) plays a significant role in central nervous system inflammation and brain damage after cerebral ischemia.
  • IL-1 expression elevates during both early and chronic stages of cerebral infarction (CI).
  • Genetic variations in IL-1alpha, IL-1beta, and IL-1 receptor antagonist (IL-1ra) genes are associated with inflammatory diseases.

Purpose of the Study:

  • To investigate the association between polymorphisms in IL-1alpha, IL-1beta, and IL-1ra genes and the risk of cerebral infarction (CI).
  • To determine if specific genotypes of these cytokines are potential genetic markers for CI in the Korean population.

Main Methods:

  • Genotyping of IL-1alpha (-889), IL-1beta (+3,953), and IL-1ra polymorphisms was performed.

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  • A case-control study design was used, comparing 363 CI patients with 640 age- and gender-matched controls.
  • Statistical analysis included chi-squared tests and odds ratio calculations to assess genetic associations.

    • Main Results:

    • A significant association was found between IL-1alpha (-889) allele 2 carriers and an increased risk of CI (OR = 1.5, P = 0.018).
    • IL-1alpha (-889) allele 2 carriers, particularly those without IL-1ra allele 2, showed a further increased relative risk for CI (OR = 1.7, P = 0.005).
    • No significant association was observed between IL-1beta (+3,953) polymorphism and CI risk.

    Conclusions:

    • IL-1alpha (-889) and IL-1ra gene polymorphisms are significant factors in the development of cerebral infarction (CI) in Koreans.
    • These genetic variations may serve as predictive markers for CI susceptibility.
    • Further research is warranted to elucidate the precise mechanisms linking these polymorphisms to CI pathogenesis.