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Curvularia haloperoxidase: antimicrobial activity and potential application as a surface disinfectant
Eva H Hansen1, Line Albertsen, Thomas Schäfer
1Novozymes A/S, DK-2880 Bagsvaerd, Denmark. ehh@dfu.min.dk
Applied and Environmental Microbiology
|August 7, 2003
Summary
The Curvularia haloperoxidase system effectively eliminates bacteria, yeasts, and fungi. This antimicrobial enzyme system shows rapid action and potential for disinfecting contact lenses and medical devices.
Area of Science:
- Biochemistry
- Microbiology
- Enzymology
Background:
- Antimicrobial resistance necessitates novel sanitizing agents.
- Haloperoxidases are enzymes that catalyze halogen oxidation.
Purpose of the Study:
- To evaluate the Curvularia haloperoxidase system as a sanitizing agent.
- To assess its efficacy against various microorganisms and on surfaces.
Main Methods:
- The Curvularia haloperoxidase system was tested with hydrogen peroxide.
- Microbial reduction was quantified using colony-forming units (CFU).
- Activity was assessed in suspension and on contact lens surfaces.
Main Results:
- Significant log-unit reductions in bacteria, yeasts, and fungi were observed.
- The system effectively killed bacteria adhered to contact lenses.
- Antimicrobial activity was rapid but transient, lasting less than 10 minutes.
Conclusions:
- The Curvularia haloperoxidase system demonstrates potent antimicrobial properties.
- It shows promise for applications in disinfection, such as for contact lenses and medical devices.