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[Lung Findings In Experimental Paragonimiasis]
Won Young Choi1, Ok Ran Lee, Young Kwan Jin
1Catholic Institute of Parasitic Diseases, Korea.
Kisaengch'Unghak Chapchi. the Korean Journal of Parasitology
|December 1, 1979
Summary
This study details the lung changes in dogs and cats infected with Paragonimus westermani. Key findings include early pleural inflammation and later lung parenchymal lesions, with cyst formation observed over time.
Area of Science:
- Veterinary Pathology
- Parasitology
- Comparative Pathology
Background:
- Paragonimiasis is a parasitic lung disease caused by Paragonimus trematodes.
- Understanding the sequential pathological changes is crucial for diagnosis and treatment.
Purpose of the Study:
- To elucidate the sequential pathological changes in the lungs of dogs and cats experimentally infected with Paragonimus westermani.
- To document the gross and microscopic findings at various time intervals post-infection.
Main Methods:
- Experimental infection of 15 dogs and 15 cats with Paragonimus westermani metacercariae.
- Necropsy and histopathological examination of lungs at 15, 20, 30, 45, 60, 90, and 120 days post-infection.
Main Results:
- No qualitative differences in pathology were observed between dogs and cats.
- Early findings (20 days) included fibrinous pleuritis and hemorrhage; juvenile worms were in the pleural cavity.
- Worms were identified in lung parenchyma by 30 days, associated with hemorrhage and bronchopneumonia. Cyst formation with inflammation and epithelialization occurred by 2 months.
- Bronchiolitis and vascular sclerosis were also noted.
Conclusions:
- Paragonimus westermani infection induces progressive pathological changes in canine and feline lungs.
- The study provides a detailed timeline of lesion development, from initial pleural reactions to mature cyst formation within the lung parenchyma.