Related Experiment Videos
Design of intelligent nucleobases and DNA HOMO mapping
1Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606-8501, Japan.
Nucleic Acids Research. Supplement (2001)
|August 9, 2003
Abstract:
We have designed a new nucleobase, benzodeazaadenine (BDA) that has a stronger charge transport ability than guanine and is not destroyed during charge transport process. By incorporating this new nucleobase into DNA, we demonstrated a protocol for real DNA nano-wire that is far superior to natural DNA. We also demonstrated that the selectivity for the interaction of Mn(II) ion with guanine N7 in G runs is a HOMO-controlled process, and as a consequence, the selectivity for G-metal ion interactions obtained by 15N-NMR studies would directly reflect the HOMO distribution of G-containing sequences in B-DNA.