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Updated: Aug 17, 2026

Using Whole Mount in situ Hybridization to Link Molecular and Organismal Biology
12:50

Using Whole Mount in situ Hybridization to Link Molecular and Organismal Biology

Published on: March 31, 2011

Development of novel whole-mount in situ hybridization (WISH)

Hisafumi Ikeda1, Madoka Tonosaki, Akinori Sugiyama

  • 1Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

Nucleic Acids Research. Supplement (2001)
|August 9, 2003
PubMed

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...