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Anti-HIV-1 activity of L-DNA quadruplex
Hidehito Urata1, Tetsuya Kumashiro, Toru Otake
1Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Nucleic Acids Research. Supplement (2001)
|August 9, 2003
Abstract:
Zintevir is a DNA 17mer that forms a quadruplex and shows strong anti-human immunodeficiency virus (HIV)-1 activity. The quadruplex formation is thought to be essential for the anti-HIV-1 activity of Zintevir. We synthesized the enantiomer of Zintevir and evaluated its structure and anti-HIV-1 activity. The results showed that the enantiomer has anti-HIV-1 activity comparable to that of Zintevir although it forms the mirror image quadruplex structure of Zintevir.