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Synthesis of a novel anticancer prodrug designed to target telomerase sequence
Satyendra Mishra1, Snehlata Tripathi, Krishna Misra
1Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Nucleic Acids Research. Supplement (2001)
|August 9, 2003
Abstract:
A curcumin conjugate viz. 1,7-bis (4-O-glycinoyl-3-methoxyphenyl)-1,6- heptadiene-3, 5, dione (I) was synthesised and after attachment of linker (-CH2-CH2-OH) phosphitylated. This unit was attached to the deoxy-11 mer, 5'-GTT AGG GTT AG-3', a complementary sequence of telomerase RNA template. Its hybridisation with the telomerase RNA sequence, 5'-CUA ACC CUA AC-3' has been studied employing Tm.