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Immediate and delayed hypersensitivity in chronic dermatophytosis.

G W Sorensen, H E Jones

Archives of Dermatology

|January 1, 1976

Summary

Men with chronic fungal skin infections show reduced delayed hypersensitivity (DH) responses. This immune system defect is specific to certain antigens, particularly fungal ones like trichophytin.

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Area of Science:

Immunology
Dermatology
Mycology

Background:

Chronic dermatophytosis is a common fungal skin infection.
Cell-mediated immunity, including delayed hypersensitivity (DH), plays a role in fungal infections.
The immune status of individuals with chronic dermatophytosis is not fully understood.

Purpose of the Study:

To investigate delayed hypersensitivity (DH) responses to common antigens in men with chronic dermatophyte infections.
To determine if chronic fungal infections impair cell-mediated immunity.

Main Methods:

Delayed hypersensitivity (DH) testing was performed on 38 men with chronic dermatophyte infections and 20 healthy controls.
Seven common antigens were used, including trichophytin, mumps antigen, and Rhus oleoresin.
Skin test reactions were assessed to measure DH responses.

Main Results:

The infected group showed a significantly reduced DH response to trichophytin compared to controls.
A decreased DH response was also observed in the infected group to mumps antigen and Rhus oleoresin.
Two individuals (5%) in the infected group exhibited anergy to all tested antigens.

Conclusions:

Patients with chronic dermatophytosis exhibit a specific defect in DH to trichophytin.
Cell-mediated immune responses to other antigens may also be decreased in these patients.
Chronic fungal skin infections can lead to a measurable impairment of delayed hypersensitivity.

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