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Design of an artificial restriction enzyme having simultaneous DNA cleavage activity
1Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Nucleic Acids Symposium Series
|August 9, 2003
Abstract:
We designed dimeric distamycin linked hydroxamic acid (DDHA)-metal complexes and investigated double strand simultaneous cleavage. Compared as distamycin linked hydroxamic acid (DHA)-metal complex, DDHA-metal complex cleaved DNA at the same level of DHA-metal complex without double strand simultaneous cleavage.