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Updated: Sep 20, 2026
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Preclinical models for chemoprevention of colon cancer
Eugene W Gerner1, Natalia A Ignatenko, David G Besselsen
1Arizona Radiation Oncology, The University of Arizona, 1515 N Campbell, P.O. Box 240524, Tucson, AZ 85724, USA.
Abstract:
Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factors for colon cancer have been described. This information has been exploited to develop experimental cell and rodent models which recapitulate features of human colon cancer. In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention.
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