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[From clone selection to danger model].

Yue Huang¹, Li-ping Zhu, Wei Zhang

¹Department of Clinical Medicine, PUMC, Beijing 100730, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae

|August 9, 2003

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Understanding the dynamic balance between immune response and immune tolerance is crucial. This review explores historical models of immunological balance, offering insights into the human immune system

Area of Science:

Immunology
Systems Biology

Context:

The human immune system requires a delicate balance between mounting effective responses against pathogens and maintaining self-tolerance to prevent autoimmunity.
Understanding this dynamic equilibrium is a long-standing challenge in immunological research.

Purpose:

To provide a historical overview of scientific models developed since the 1950s to explain the regulation of immune response and immune tolerance.
To trace the evolution of immunological thought regarding the maintenance of immune homeostasis.

Summary:

This mini-review introduces various theoretical models proposed over the past half-century to understand how the human immune system dynamically balances immune responses with immune tolerance.
It highlights the historical progression of scientific inquiry into immune system regulation.

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Impact:

Offers a concise historical perspective on key immunological concepts.
Provides a foundational understanding for researchers studying immune system dynamics and dysregulation.