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[Weekly cyclophosphamide pulse therapy combined with corticosteroids in the treatment of pemphigus]

G Q Jia¹, Z Q Chen, H L Li

¹Department of Clinical Research, Institute of Dermatology, CAMS, PUMC, Nanjing 210042, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae

|August 9, 2003

Abstract

Objective:

To investigate the better regimen of combined cyclophosphamide pulse therapy with corticosteroids in the treatment of Pemphigus.

Methods:

Intravenous cyclophosphamide was given weekly in a dosage of 600 mg to those Pemphigus patients whose conditions couldn't be improved by corticosteroids (oral prednisone 1.2-1.5 mg/kg/d) alone.

Results:

Ten patients with Pemphigus received weekly cyclophosphamide therapy in addition to corticosteroid. Patients conditions improved quickly, without side effects.

Conclusions:

Cyclophosphamide weekly pulse therapy combined with corticosteroids is a good regimen in the treatment of Pemphigus.

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