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CD8 T cells and aging.

Rita B Effros1, Zeling Cai, Phyllis-Jean Linton

  • 1Department of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, USA.

Critical Reviews in Immunology
|August 9, 2003
PubMed
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Aging immune systems (immunosenescence) show reduced responsiveness and function, increasing elderly risks for infections, autoimmunity, and cancer. This review details age-related CD8 T-cell changes impacting immunity.

Area of Science:

  • Immunology
  • Gerontology
  • Cellular Biology

Background:

  • Immune system aging (immunosenescence) leads to reduced responsiveness and functional dysregulation.
  • These changes increase elderly susceptibility to infections, autoimmunity, and cancer.
  • While B cell alterations are minor, T-cell compartment changes significantly impact immune responses.

Purpose of the Study:

  • To review age-related changes in the CD8 T-cell subset.
  • To discuss the impact of these changes on immune function in aging.
  • To highlight distinct patterns of immunosenescence in humans and mice.

Main Methods:

  • Review of existing literature on immunosenescence and T-cell biology.
  • Focus on CD8 T-cell subset alterations.

Related Experiment Videos

  • Consideration of age-related changes in thymic function, cellular homeostasis, T-cell activation, replicative senescence, and oligoclonal expansions.

    • Main Results:

    • Aging significantly impacts CD8 T-cell function through various mechanisms.
    • Age-related changes include thymic involution, altered cellular homeostasis, and shifts in T-cell populations.
    • Replicative senescence and oligoclonal expansions contribute to diminished CD8 T-cell effectiveness.

    Conclusions:

    • Age-associated alterations in CD8 T cells are a primary driver of immunosenescence.
    • Dysfunctional CD8 T cells contribute to increased disease susceptibility in the elderly.
    • Understanding these changes is crucial for addressing age-related immune decline.