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Replicative helicase loaders: ring breakers and ring makers
Megan J Davey1, Mike O'Donnell
1Howard Hughes Medical Institute, 1230 York Ave., New York, NY 10021, USA.
Current Biology : CB
|August 9, 2003
Abstract:
Helicase loaders transfer the ring-shaped replicative helicases onto DNA. They assort into two classes: ring breakers, which place stabile hexameric rings on DNA via transient gaps at subunit interfaces; and helicase makers, which assemble hexameric rings around DNA from monomeric helicase units.