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Demineralized perforated bone implants in craniofacial surgery.

K E Salyer1, E Gendler, J L Menendez

  • 1Humana International Craniofacial Institute, Humana Hospital-Medical City Dallas, Texas.

The Journal of Craniofacial Surgery
|September 1, 1992
PubMed
Summary

Demineralized perforated allogeneic bone implants show promise as an alternative to autogenous bone grafts in craniofacial reconstruction. Complications were minimal, primarily delayed wound healing in a small patient group.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Craniofacial Surgery

Background:

  • Autogenous bone grafting is a common method for skeletal reconstruction.
  • Limitations of autogenous bone grafts include donor site morbidity and limited availability.
  • Allogeneic bone presents an alternative source for bone grafting materials.

Purpose of the Study:

  • To evaluate the efficacy and safety of demineralized perforated allogeneic bone implants.
  • To assess the use of these implants in various craniofacial and skeletal reconstruction procedures.

Main Methods:

  • A total of 248 demineralized perforated allogeneic bone implants were used in 80 procedures on 72 patients between July 1990 and September 1991.
  • Implants were utilized as inlay grafts in the cranial vault and maxillary complex, and as onlay grafts for contouring/augmentation in orbital, nasal, paranasal, temporal, and malar areas.

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  • The processing technology for these implants was detailed.

    • Main Results:

    • The study involved patients with craniofacial deformities, post-cleft lip/palate defects, post-tumor resection defects, and trauma-related deformities.
    • Complications were infrequent, with only 6 patients experiencing delayed wound healing.
    • The implants were used successfully in diverse craniofacial and skeletal reconstruction scenarios.

    Conclusions:

    • Demineralized perforated allogeneic bone implants are an encouraging alternative to autogenous bone grafting.
    • Further clinical and experimental research is warranted to fully understand the potential of this biomaterial.