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Anaphylaxis: risk factors for recurrence.

R J Mullins1

  • 1University of Canberra (Associate Professor), Canberra, University of Sydney (Senior Lecturer), Sydney, Australian National University (Clinical Senior Lecturer), Canberra, Australia. rmullins@allergycapital.com.au

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|August 13, 2003
PubMed
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Anaphylaxis recurrence affects 1 in 12 patients annually, with poor adrenaline use. New triggers and psychiatric issues can also arise in anaphylaxis patients.

Area of Science:

  • Allergy and Immunology
  • Epidemiology

Background:

  • Limited research exists on anaphylaxis incidence and recurrence rates.
  • Understanding these patterns is crucial for public health management.

Purpose of the Study:

  • To determine the incidence of anaphylaxis in a defined population.
  • To identify risk factors associated with anaphylaxis recurrence.

Main Methods:

  • A prospective study involving 432 patients with anaphylaxis.
  • Follow-up surveys were conducted to gather recurrence data.
  • Epidemiological data on incidence and recurrence rates were analyzed.

Main Results:

  • The incidence of new anaphylaxis cases was estimated at 9.9 episodes per 100,000 patient-years.

Related Experiment Videos

  • Recurrence rates were 57 overall and 10 serious episodes per 100 patient-years.
  • Food (61%) and stinging insects (20.4%) were primary triggers; wheat/exercise sensitivity posed the highest recurrence risk.
  • Adrenaline auto-injector carrying and usage compliance was low (3/4 carried, 1/2 used in emergencies).

    • Conclusions:

    • Approximately 1 in 12 anaphylaxis patients experience recurrence annually, with 1 in 50 requiring hospitalization or adrenaline.
    • Poor adherence to carrying and using adrenaline auto-injectors was observed.
    • Anaphylaxis patients may develop new triggers or experience psychiatric comorbidities.