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Synthesis of 2-(pyrimidin-4-yl)indoles
Laura Hernández Franco1, Jorge Alejandro Palermo
1Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Chemical & Pharmaceutical Bulletin
|August 13, 2003
Abstract:
The synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as the key reaction.