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Published on: June 15, 2018
Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis
A Lannergard1, G Friman, A Larsson
1Department of Medical Sciences, Infectious Diseases, Uppsala University Hospital, S-751 85 Uppsala, Sweden. anders.lannergard@medicin.uas.lul.se
Purpose:
We compared serum amyloid A (SAA) protein, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha as inflammatory markers for pyelonephritis and cystitis.
Materials And Methods:
SAA, CRP, IL-6 and TNF-alpha were determined in serum from 69 consecutive patients with acute pyelonephritis (37) and acute cystitis (32) on admission to an infectious disease clinic and on examination at a primary health care center, respectively. Healthy blood donors served as controls.
Results:
SAA showed a systemic inflammatory response in cystitis in 90% of patients compared with 23%, 42% and 0% for CRP, IL-6 and TNF-alpha, respectively. SAA and CRP had equally high efficiencies (0.96 and 0.94, respectively) for discriminating between pyelonephritis and cystitis while efficiencies for IL-6 (0.85) and TNF-alpha (0.91) were lower.
Conclusions:
SAA is a sensitive systemic marker in cystitis but is still useful in detecting pyelonephritis.
