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Updated: Jun 8, 2026
A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
Published on: April 12, 2019
[Study on pulmonary delivery system of salmon calcitonin in rats]
1Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Objective:
To study the serum calcitonin(CT) levels in vivo after pulmonary delivery to rats and the effects of absorption enhancers.
Methods:
Salmon calcitonin (sCT) solution was delivered by intramuscular injection or intratracheal administration to rats. The absorption of sCT was determined by radioimmunoassay method. Changes in serum drug levels after the pulmonary administration of sCT with various absorption enhancers or in different pH conditions were investigated.
Results:
Compared with intramuscular administration, the relative bioavailability of sCT solution (2 micrograms.kg-1) given by intratracheal route was 121.0%. Transpulmonary absorption of sCT solution, with some absorption enhancers (Brij78, sodium cholate, lecithin, chitosan and sodium caprylate) or under acidic conditions (pH3.0), was significantly greater than the values obtained in controls.
Conclusion:
sCT solution showed higher bioavailability after pulmonary administration.
