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Sex variation in ascorbic acid catabolism.

M G Muddeshwar1, N Nath, S N Chari

  • 1Department of Biochemistry, Indira Gandhi Medical College, Nagpur.

Indian Journal of Physiology and Pharmacology
|October 1, 1992
PubMed
Summary
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Male rats exhibit higher ascorbic acid (vitamin C) levels in the liver and urine compared to females. This study investigated sex-based differences in vitamin C metabolism and related enzyme activities.

Area of Science:

  • Biochemistry
  • Animal Physiology
  • Nutritional Science

Background:

  • Ascorbic acid (vitamin C) is an essential nutrient with crucial physiological roles.
  • Understanding factors influencing ascorbic acid metabolism, such as sex, is important for nutritional and physiological research.

Purpose of the Study:

  • To investigate sex-based differences in ascorbic acid, dehydroascorbic acid, and diketogulonic acid levels in rats.
  • To examine sex-related variations in the activity of enzymes involved in ascorbic acid metabolism.

Main Methods:

  • Pair-fed male and female albino rats were used.
  • Ascorbic acid, dehydroascorbic acid, and diketogulonic acid were quantified in liver, urine, and blood.
  • Enzyme activities (hepatic and renal 2, 3-diketoaldonate decarboxylase, hepatic dehydroascorbatase) were measured.

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Main Results:

  • Male rats showed significantly higher concentrations of ascorbic acid in the liver and urine than females.
  • No significant sex differences were observed in dehydroascorbic acid and diketogulonic acid levels.
  • Activities of hepatic and renal 2, 3-diketoaldonate decarboxylase and hepatic dehydroascorbatase were higher in males.

Conclusions:

  • Significant sex-based differences exist in ascorbic acid metabolism and related enzyme activities in rats.
  • These findings suggest a potential sex-specific regulation of vitamin C homeostasis and catabolism.