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Sickle cell disease: loss of the blood's WD40?

Jack R Lancaster1

  • 1Center for Free Radical Biology, Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. doctorno@uab.edu

Trends in Pharmacological Sciences
|August 14, 2003
PubMed

Sickle cell disease (SCD) is characterized by malformed erythrocytes and results in many vascular complications, including the lysis of a minor proportion of these cells, liberating free hemoglobin, which is a potent scavenger of nitric oxide (NO). SCD involves inflammatory activation, including the upregulation of vascular coagulation. Because NO possesses important anti-coagulant and anti-adhesion properties, the increased scavenging of NO in SCD undoubtedly is a major contributor to the pathology of this disease.

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