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Carbonylative Sonogashira coupling of terminal alkynes with aqueous ammonia
Mohamed S Mohammed Ahmed1, Atsunori Mori
1Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8503, Japan.
Organic Letters
|August 15, 2003
Abstract:
[reaction: see text] Carbonylative coupling of phenylethyne with 4-methoxy-1-iodobenzene in the presence of 1 mol % PdCl(2)(PPh(3))(2), 2 equiv of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding alpha,beta-alkynyl ketone in 72% isolated yield after stirring at room temperature for 41 h, while noncarbonylative coupling product is not obtained.