Related Experiment Video

Updated: Jul 6, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
10:53

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

Atrial plasmacytoma and hypercalcemia

Lori A Brame1, Rohit Dwivedi, Todd W Rice

  • 1Indiana University School of Medicine, Division of Endocrinology, Emerson Hall 421, 545 Barnhill Drive, Indianapolis, IN 46202, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|August 15, 2003
PubMed

Insights

This case report details a patient with hypercalcemia caused by multiple myeloma and an unusual atrial plasmacytoma. It highlights the importance of considering plasmacytoma in multiple myeloma diagnoses when localized symptoms appear.

Area of Science:

  • Oncology
  • Hematology
  • Cardiology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Hypercalcemia is a common complication of multiple myeloma.
  • Plasmacytomas are localized plasma cell tumors.

Observation:

  • A 48-year-old woman presented with hypercalcemia, anemia, thrombocytopenia, and renal insufficiency.
  • Diagnosed with multiple myeloma, she developed a subdural hematoma and atrial plasmacytoma.
  • Autopsy revealed disseminated myeloma and the atrial plasmacytoma.

Findings:

  • The patient's hypercalcemia was attributed to multiple myeloma.
  • An atrial plasmacytoma was identified as an associated finding.
  • The case illustrates rare presentations of multiple myeloma.

Implications:

  • This case underscores the need to consider plasmacytomas in the differential diagnosis of multiple myeloma.
  • Recognizing plasmacytomas is crucial for accurate diagnosis and management.
  • Further research into the extraskeletal manifestations of multiple myeloma is warranted.
Abstract

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