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Weight loss reduces tissue factor in morbidly obese patients
Christoph W Kopp1, Hans-Peter Kopp, Sabine Steiner
12nd Department of Medicine, Angiology Division, University of Vienna, General Hospital (AKH), Waehringer Guertel 18/20, A-1090 Vienna, Austria. christoph.kopp@univie.ac.at
Obesity Research
|August 15, 2003
Summary
Weight loss significantly reduces tissue factor (TF) and improves glucose metabolism in obese patients. This suggests TF reduction may lower cardiovascular risk linked to obesity.
Area of Science:
- Cardiovascular Science
- Metabolic Syndrome Research
- Hemostasis and Thrombosis
Background:
- Obesity is linked to metabolic syndrome and increased cardiovascular risk.
- The tissue factor (TF) pathway plays a role in hemostasis and thrombosis.
- Understanding TF in obesity is crucial for risk assessment and management.
Purpose of the Study:
- To investigate the tissue factor (TF) pathway in patients with clinical obesity and metabolic syndrome.
- To assess the impact of weight loss on TF and related metabolic parameters.
Main Methods:
- Thirty-seven morbidly obese patients undergoing gastroplasty were studied.
- Hemostatic, metabolic, and inflammatory markers were measured preoperatively and postoperatively (14 months).
- Subgroup analysis was performed based on preoperative glucose tolerance.
Main Results:
- Weight loss significantly reduced plasma TF, coagulation factor VII, and prothrombin fragment F1.2.
- Glucose metabolism normalized in 50% of patients with prediabetes or diabetes.
- Postoperative TF reduction correlated with decreased thrombin formation markers.
Conclusions:
- Procoagulant TF is significantly reduced following weight loss in obese individuals.
- Reduced TF may contribute to the decreased cardiovascular risk observed with weight loss.
- TF levels and their reduction are associated with glucose tolerance status.