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Correlation between serum resistin level and adiposity in obese individuals
Koichiro Azuma1, Fuminori Katsukawa, Shuji Oguchi
1Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. SNA12474@nifty.com
Obesity Research
|August 15, 2003
Summary
Serum resistin levels are higher in obese individuals and correlate with weight changes. This suggests resistin may be a factor in human obesity and insulin resistance.
Area of Science:
- Endocrinology
- Metabolic Syndrome Research
Background:
- Resistin, a hormone, is implicated in insulin resistance in animal models.
- Its role in human metabolic disorders, particularly obesity and insulin resistance, requires further investigation.
Purpose of the Study:
- To investigate the association between serum resistin levels and body composition, insulin resistance, and obesity phenotypes in humans.
- To explore the relationship between resistin and changes in these parameters following weight reduction.
Main Methods:
- Cross-sectional study comparing 64 obese and 15 lean individuals.
- Longitudinal follow-up of 35 obese subjects undergoing a 1.5-year weight reduction program (diet and exercise).
- Measurements included serum resistin, body mass index (BMI), body composition, fat distribution, and insulin sensitivity indices via oral glucose tolerance tests.
Main Results:
- Obese subjects exhibited significantly higher serum resistin levels compared to lean individuals (p < 0.01).
- A positive correlation was observed between resistin levels and BMI in the combined cohort (p < 0.01).
- Longitudinal analysis revealed that changes in serum resistin positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and glucose/insulin levels (p < 0.05 for all).
Conclusions:
- Serum resistin levels are linked to human adiposity.
- Resistin is a potential candidate factor contributing to human insulin resistance.