Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ketogenic diet for epilepsy.

R Levy1, P Cooper

  • 1Royal Albert Edward Infirmary, Wigan Lane, Wigan, UK, WN1 2NN.

The Cochrane Database of Systematic Reviews
|August 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment and management of acute epididymo-orchitis in the emergency department.

Irish medical journal·2025
Same author

Search for Leptonic Decays of Dark Photons at NA62.

Physical review letters·2024
Same author

Effect of Blood Decontamination Procedures on the Microshear Bond Strength of Resin-modified Glass Ionomer Cement to Resin Composite.

Operative dentistry·2024
Same author

Search for Lepton Number and Flavor Violation in K^{+} and π^{0} Decays.

Physical review letters·2021
Same author

Applications of a Novel Microangioscope for Neuroendovascular Intervention.

AJNR. American journal of neuroradiology·2020
Same author

The stable component of maternal depressive symptoms predicts offspring emotional and behavioral symptoms: a 9-years longitudinal study.

BMC psychology·2020
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

No randomized controlled trials (RCTs) currently support the ketogenic diet for epilepsy. While observational studies suggest benefits, further RCTs are needed to validate these findings for difficult-to-treat epilepsy.

Area of Science:

  • Neurology
  • Dietary Science
  • Clinical Trials

Background:

  • The ketogenic diet, high in fat and low in carbohydrates, is proposed to reduce seizure frequency.
  • It is primarily used in pediatric epilepsy cases resistant to antiepileptic drugs.

Purpose of the Study:

  • To systematically review evidence from randomized controlled trials (RCTs) on the efficacy of ketogenic diets for epilepsy.

Main Methods:

  • Comprehensive searches of major scientific databases (Cochrane Epilepsy Group, CENTRAL, MEDLINE, EMBASE) were conducted up to March 2003.
  • Inclusion criteria focused on randomized controlled trials involving individuals with epilepsy on ketogenic diets.
  • Data extraction and analysis were planned for independent review by two researchers.

Related Experiment Videos

Main Results:

  • The systematic search identified no randomized controlled trials evaluating ketogenic diets for epilepsy.

Conclusions:

  • Currently, there is insufficient high-quality evidence from RCTs to confirm the effectiveness of ketogenic diets for epilepsy.
  • Observational studies indicate potential seizure reduction, but these require validation through rigorous RCTs.
  • The ketogenic diet remains a potential therapeutic option for individuals with refractory epilepsy on multiple antiepileptic drugs.