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Extrapulmonary sarcoidosis with chronic renal failure
Nilgun Erten1, Bulent Saka, Bahar Artinesen
1Department of Internal Medicine, Istanbul Medical School, Istanbul University, Millet Street, Capa, 34270, Istanbul, Turkey
European Journal of Internal Medicine
|August 16, 2003
Summary
This case study highlights extrapulmonary sarcoidosis in a young woman with a history of tuberculosis. It emphasizes the varied kidney manifestations and the effectiveness of corticosteroid treatment for this rare condition.
Area of Science:
- Nephrology
- Immunology
- Ophthalmology
Background:
- Presents a rare case of extrapulmonary sarcoidosis in a young woman.
- Patient had a history of tuberculosis treated 15 years prior.
- Initial diagnosis of sarcoidosis was based on liver biopsy.
Purpose of the Study:
- To describe a unique presentation of extrapulmonary sarcoidosis.
- To highlight the diverse renal manifestations of sarcoidosis.
- To underscore the importance of considering sarcoidosis in patients with unexplained granulomatous disease.
Main Methods:
- Case report and review of relevant literature.
- Histopathological examination of biopsy specimens (liver, kidney, lymph node).
- Clinical assessment including ophthalmological evaluation for uveitis.
Main Results:
- Noncaseating granulomatous lesions identified in kidney, intra-abdominal lymph node, and previous liver biopsy.
- Patient developed bilateral visual loss due to uveitis.
- Renal involvement presented with features of hypercalcemic nephropathy and granulomatous interstitial nephritis.
Conclusions:
- Extrapulmonary sarcoidosis can present with varied and severe manifestations, including renal and ocular involvement.
- Renal sarcoidosis has diverse presentations, including nephropathy, interstitial nephritis, tubular dysfunction, and glomerulonephritis.
- Corticosteroids remain the primary treatment for sarcoidosis, including its extrapulmonary forms.