Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic activity and the underlying action potentials in sympathetic nerves: a simulation.

Xiaorui Tang1, Ankit R Chander, Lawrence P Schramm

  • 1Department of Biomedical Engineering, The Johns Hopkins School of Medicine, 606 Traylor Bldg., 720 Rutland Ave., Baltimore, Maryland 21205, USA.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|August 16, 2003
PubMed
Summary

Simulations reveal that sympathetic nerve activity integrals and variances correlate with the number of contributing action potentials. This provides insights into sympathetic nervous system processing and analysis methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facilitators to and experience of psychological resilience during disease response among people with diabetes: a mixed-methods study using resilience framework.

Frontiers in psychology·2026
Same author

ChERF017, an ERF transcription factor, confers cadmium stress tolerance in Cerasus humilis.

BMC plant biology·2026
Same author

Variations in the Gut Microbiota of Stray and Domestic Cats.

Animals : an open access journal from MDPI·2026
Same author

Periglomerular afferent innervation of the mouse renal cortex.

Frontiers in neuroscience·2023
Same author

FDA Perspectives on the Regulation of Neuromodulation Devices.

Neuromodulation : journal of the International Neuromodulation Society·2020
Same author

Interoception and Mental Health: A Roadmap.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2018

Area of Science:

  • Neuroscience
  • Computational Biology
  • Physiology

Background:

  • Understanding sympathetic nerve activity is crucial for central nervous system processing.
  • Direct experimental determination of the relationship between nerve activity and action potentials is challenging.

Purpose of the Study:

  • To simulate sympathetic nerve activity to understand the relationship between recorded activity and contributing action potentials.
  • To evaluate the effectiveness of cluster analysis in quantifying sympathetic bursts using simulated data.

Main Methods:

  • Simulated summed action potentials from 300 axons to mimic sympathetic activity.
  • Analyzed simulated bursts for integrals, variances, and amplitudes.
  • Applied Fourier transform to assess spectral amplitude relationships.

Related Experiment Videos

Main Results:

  • Burst integrals and signal variances showed a linear correlation with the number of contributing action potentials.
  • Burst amplitudes were less correlated with the number of action potentials.
  • A linear relationship was found between average action potentials and the integral of amplitude spectra.

Conclusions:

  • Simulation closely replicated actual sympathetic activity, enabling detailed analysis.
  • Cluster analysis effectively quantifies sympathetic bursts, with integrals correlating to action potential counts.
  • Brief recordings may suffice for detecting significant changes in sympathetic activity.