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Updated: Sep 7, 2026
A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
[Pathologic diagnosis of primary small round cell tumors of the bone]
Jia Na1, Wanzhong Zou, Zhiwei Fang
1Department of Pathology, Peking University First Hospital, Beijing 100034, China. jna4495@hotmail.com
Objective:
To study the diagnosis and differentiation of primary small round cell tumors of bone.
Methods:
Thirty-nine cases were studied by light microscopy and immunochemistry of O13, NSE, S-100, Actin and LCA.
Results:
20/22 cases of EW/PNET were positive for O13.16/22 cases of EW/PNET and one case of small cell osteosarcoma were positive for NSE. S-100 was positive in EW/PNET, small cell osteosarcoma and mesenchymal chondrosarcoma. All malignant lymphomas were positive for LCA. 6 cases of small cell osteosarcoma have osteoid production. Islands of cartilage were found in mesenchymal chondrosarcoma.
Conclusion:
O13 is a specific valuable marker for the diagnosis of EW/PNET. Histologic features of the osteoid in osteosarcoma and the cartilage in mesenchymal chondrosarcoma are important for the diagnosis.
