Related Experiment Video
Updated: Sep 20, 2026

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
The oral health status of children undergoing hemodialysis treatment
Fahinur Ertuğrul1, Ciğdem Elbek-Cubukçu, Ertuğrul Sabah
1Department of Pedodontics, Faculty of Dentistry, Ege University, Izmir, Turkey.
Insights
Children with end-stage renal disease (ESRD) exhibit lower oral bacteria levels and higher salivary buffer capacity, potentially explaining their reduced risk of dental caries. Despite this, oral health education remains crucial for these patients.
Area of Science:
- Pediatric Nephrology
- Oral Health
- Microbiology
Background:
- Children with end-stage renal disease (ESRD) often present with unique oral health profiles.
- Previous observations suggest a lower prevalence of dental caries in this population, but the underlying mechanisms require investigation.
Purpose of the Study:
- To investigate the oral status of children with ESRD.
- To determine the causes of low caries prevalence in children with ESRD.
- To compare oral health parameters between children with ESRD and a healthy control group.
Main Methods:
- The study included 38 children (aged 4-17 years) with ESRD and a control group (n=38).
- Oral status was assessed using the Cariogram (CRT) bacteria and buffer test.
- Dmft, DMFT, gingival, and plaque indices were compared between groups.
Main Results:
- Children with ESRD showed significantly lower dmft and improved gingival status compared to controls.
- High salivary buffer capacity (89.5%) and significantly lower levels of cariogenic Streptococcus mutans and Lactobacilli were observed in the ESRD group.
- Severe enamel hypoplasia was noted in the ESRD group, though DMFT and plaque indices did not differ significantly.
Conclusions:
- Increased salivary urea concentrations in children with ESRD may contribute to reduced cariogenic microorganisms, explaining the lower caries prevalence.
- Despite a lower need for dental treatment, these children require comprehensive oral health education and hygiene instruction to optimize their overall oral well-being.
Abstract:
In this study, we investigated the oral status of children suffering from end-stage renal disease (ESRD) with the aim of determining the causes of low caries prevalence in this population (using the CRT bacteria and buffer test), and compared results with a control group (n=38). In the study group, there were 38 children (aged 4-17 years) who were being treated in pediatric nephrology units at three different hospitals in Izmir, Turkey. The study and control groups did not significantly differ in daily tooth brushing frequency and periodic dental check-up frequency. Severe enamel hypoplasia was present in the study group. Dmft, DMFT, gingival and plaque indices were compared statistically in mixed dentition stage with the control group and dmft and gingival status showed a statistically significant difference (p<0.05). The differences among groups for DMFT and plaque indices were not statistically significant. In the study group, high salivary buffer capacity was found in 89.5% of patients. Salivary levels of cariogenic streptococcus mutans and lactobacilli in the study group were significantly lower than in the control group. In conclusion, probably due to increased concentrations of antibacterial chemicals such as urea in the saliva of children with ESRD, decreased levels of cariogenic microorganisms were detected. Therefore, although dental treatment need is not high, these children should receive dental health education, including oral hygiene instruction, in order to improve their overall oral health.
Related Concept Videos
Hemodialysis III: Nursing Management
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Hemodialysis II: Procedure and Complications
Hemodialysis I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease III: Interprofessional Care
