Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosome aberrations in solid tumors.

Donna G Albertson1, Colin Collins, Frank McCormick

  • 1Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA. albertson@cc.ucsf.edu

Nature Genetics
|August 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CAR-T Cell-Derived Exosomes and Cancer Immunotherapy: Advancing Production and Delivery Through Biofabrication.

Biofabrication·2026
Same author

NF1 and SPRED1/2 cooperate through RAS-MAPK-independent functions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

MMP1 and PRSS23 induce PAR<sub>2</sub> biased agonism in painful oral cancers.

Communications biology·2026
Same author

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRAS<sup>G12C</sup> suppresses PI3Kα and leads to potent tumor inhibition.

bioRxiv : the preprint server for biology·2026
Same author

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.

The Biochemical journal·2026
Same author

Dashboard Knee: Injury Mechanisms, Diagnostic Challenges, and Treatment Outcomes.

Cureus·2026
Same journal

Mutations in splicing factor gene U2AF1 rescue defective oncogene splicing in KRAS-mutant cancers.

Nature genetics·2026
Same journal

Assessing the effect of immune surveillance on clonal expansions in the blood.

Nature genetics·2026
Same journal

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.

Nature genetics·2026
Same journal

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

Nature genetics·2026
Same journal

Lineage tracing from cellular heritage to disease destiny.

Nature genetics·2026
Same journal

Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.

Nature genetics·2026
See all related articles

Chromosome aberrations are key indicators of gene changes and instability in human solid tumors. Understanding these aberrations aids in cancer progression insights and clinical advancements.

Area of Science:

  • Genetics
  • Oncology
  • Genomics

Background:

  • Chromosome aberrations are recognized as critical indicators of genomic instability and gene deregulation in human solid tumors.
  • These aberrations play a significant role in the development and progression of various cancers.

Purpose of the Study:

  • To review current knowledge on chromosome aberrations in human solid tumors.
  • To discuss the functional importance of these aberrations.
  • To explore mechanisms of aberration formation during cancer progression.
  • To highlight clinical advances derived from studying chromosome aberrations.

Main Methods:

  • Literature review of studies on chromosome aberrations in human solid tumors.
  • Analysis of functional roles and formation mechanisms.

Related Experiment Videos

  • Compilation of clinical advancements.

    • Main Results:

    • Chromosome aberrations are fundamental to cancer development, reflecting gene deregulation.
    • Specific mechanisms contribute to aberration formation during tumor progression.
    • Studies of aberrations have led to significant clinical breakthroughs.

    Conclusions:

    • Chromosome aberrations are crucial in understanding cancer biology.
    • Further research into aberration mechanisms can drive novel therapeutic strategies.
    • Clinical applications of aberration studies continue to expand.