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The prevalence of invasive candidiasis in patients with extensive burns
Abstract:
A retrospective study of patients admitted to the Singapore General Hospital Burn Unit with > 30% total body surface area burns was performed to establish the prevalence of fungal colonisation and invasive fungal disease (IFD). Forty-eight percent of patients surviving at least ten days following thermal injury had fungi isolated. IFD was documented in ten patients. Risk factors associated with the development of IFD, clues to assist in diagnosing IFD, and therapeutic options for managing IFD are reviewed.
Insights
Fungal infections are common in severe burn patients. This study found that 48% of patients with over 30% total body surface area burns had fungal colonization, with invasive fungal disease (IFD) occurring in 10 patients.
Area of Science:
- Medicine
- Infectious Diseases
- Burn Care
Background:
- Severe burns (>30% total body surface area) create a high risk for opportunistic infections.
- Fungal colonization is a known precursor to invasive fungal disease (IFD) in immunocompromised patients.
Purpose of the Study:
- To determine the prevalence of fungal colonization and invasive fungal disease (IFD) in patients with severe burns admitted to a specialized burn unit.
- To review risk factors, diagnostic clues, and therapeutic strategies for IFD in this patient population.
Main Methods:
- Retrospective study design.
- Analysis of patient data from the Singapore General Hospital Burn Unit.
- Inclusion criteria: patients with >30% total body surface area burns.
Main Results:
- Fungal isolates were found in 48% of patients surviving at least 10 days post-burn.
- Invasive fungal disease (IFD) was diagnosed in 10 patients.
- The study provides a basis for reviewing associated risk factors and diagnostic challenges.
Conclusions:
- Fungal colonization is highly prevalent in severe burn patients.
- Invasive fungal disease (IFD) is a significant concern in this population, necessitating careful monitoring and management.
- Further research into risk stratification and early diagnosis of IFD is warranted.