Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chromium as an essential element].

J Racek1

  • 1Ustav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzen. racek@fnplzen.cz

Casopis Lekaru Ceskych
|August 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

False-Positive Cardiac Troponin Elevations in Skeletal Muscle Disease: Clinical Relevance, Mechanisms, and Laboratory Approaches.

Physiological research·2025
Same author

Effect of Beer Consumption on Methylation and Redox Metabolism.

Physiological research·2022
Same author

NGAL, albumin and cystatin C during cisplatin therapy.

Physiological research·2020
Same author

Creatine Kinase and Myoglobin Levels as Indicators of Perioperative Muscle Damage during Open- and Mini-Invasive Stabilization of Thoracic and Lumbar Spine Fracture - a Prospective Randomized Study.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2020
Same author

Prognostic role of serum C-reactive protein in patients with advanced-stage NSCLC treated with pemetrexed.

Neoplasma·2017
Same author

Serum albumin is a strong predictor of survival in patients with advanced-stage non-small cell lung cancer treated with erlotinib.

Neoplasma·2016
Same journal

The personality of professor Otakar Štark in the context of the development of medical genetics in Czechoslovakia in the years 1950-1990.

Casopis lekaru ceskych·2026
Same journal

Václav Náprstek, MD - a forgotten hero.

Casopis lekaru ceskych·2026
Same journal

Professor Otto Piffl, the First Full Professor of Otology and Rhinology at the German University in Prague, passed away 100 years ago.

Casopis lekaru ceskych·2026
Same journal

Ancient sanctuary of Eileithyia, goddess of childbirth, on the island of Paros (Greece).

Casopis lekaru ceskych·2026
Same journal

European Partnership for Personalised Medicine (EP PerMed).

Casopis lekaru ceskych·2026
Same journal

Periodontitis and type 2 diabetes.

Casopis lekaru ceskych·2026
See all related articles

Trivalent chromium is an essential element crucial for glucose and lipid metabolism. It forms chromodulin, enhancing insulin signaling and improving glucose tolerance in chromium-deficient individuals, particularly those with type 2 diabetes.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Context:

  • Hexavalent chromium is known for toxic effects, but trivalent chromium (Cr(III)) is essential.
  • Cr(III) plays a vital role in glucose and lipid metabolism.
  • Recent research elucidates the molecular mechanisms of Cr(III) in insulin signaling.

Purpose:

  • To explain the molecular mechanism of trivalent chromium in insulin signaling.
  • To highlight the role of chromium in glucose and lipid metabolism.
  • To discuss the therapeutic potential of chromium supplementation.

Summary:

  • Chromium is absorbed and transported via transferrin, then enters cells via insulin-mediated transport.
  • Inside cells, chromium binds to apochromodulin to form chromodulin, which amplifies insulin receptor tyrosine kinase activity.

Related Experiment Videos

  • Chromium deficiency is linked to insulin resistance and impaired glucose/lipid metabolism, especially in type 2 diabetes.

    • Impact:

    • Chromium supplementation can improve glucose tolerance and lipid profiles in deficient individuals.
    • It is indicated for impaired glucose tolerance and type 2 diabetes, where chromium loss is elevated.
    • Organic chromium compounds like yeast extract and chromium(III) picolinate are commonly used for supplementation.