Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[A hypothesis about anti-DNA antibody].

Yutaka Tajima1

  • 1Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 20, 2003
PubMed
Summary

Anti-DNA antibodies, particularly anti-double-strand DNA antibodies, are key biomarkers for systemic lupus erythematosus (SLE). This review hypothesizes that these antibodies may cross-react with negatively charged substances in vivo, challenging their specific in vivo targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A Case of Aplastic or Twig-Like Middle Cerebral Artery Presenting with an Intracranial Hemorrhage Two Years after a Transient Ischemic Attack].

No shinkei geka. Neurological surgery·2016
Same author

Treatment of a ruptured aneurysm involved in a double origin of the posterior inferior cerebellar artery.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2015
Same author

HMGB1: A new marker for estimation of the postmortem interval.

Experimental and therapeutic medicine·2012
Same author

Coffee-induced Hypokalaemia.

Clinical medicine insights. Case reports·2011
Same author

[Anti-reticulin antibody].

Nihon rinsho. Japanese journal of clinical medicine·2010
Same author

Comparison of methods of detecting bacterial biofilm.

Clinical laboratory·2010

Area of Science:

  • Immunology
  • Molecular Biology
  • Rheumatology

Context:

  • Anti-DNA antibodies are crucial diagnostic markers for Systemic Lupus Erythematosus (SLE).
  • Current clinical detection methods utilize DNA as a target for these antibodies in vitro.
  • The in vivo targets and binding mechanisms of anti-DNA antibodies remain largely unclear.

Purpose:

  • To review current findings on anti-DNA antibodies.
  • To investigate the in vivo targets of anti-DNA antibodies.
  • To propose a hypothesis explaining the in vivo binding of anti-DNA antibodies.

Summary:

  • This review explores the in vivo targets of anti-DNA antibodies, which are highly specific for SLE in clinical diagnostics.
  • A central hypothesis suggests these antibodies may nonspecifically cross-react with negatively charged substances, such as polysaccharides, in vivo.
  • Charge interactions are proposed as the dominant mechanism for this binding.

Impact:

  • This research could redefine our understanding of anti-DNA antibody pathogenicity in SLE.
  • It may lead to the development of more accurate diagnostic and therapeutic strategies for SLE.
  • Clarifying in vivo binding could improve the specificity of autoimmune disease diagnostics.

Related Experiment Videos