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Related Experiment Videos

Fibrillary glomerulonephritis with hypocomplementemia.

Satoshi Suzuki1, Tsuneo Konta, Ryo Koizumi

  • 1First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata.

Internal Medicine (Tokyo, Japan)
|August 20, 2003
PubMed
Summary

A rare case of fibrillary glomerulonephritis associated with rheumatoid arthritis and hypocomplementemia is presented. This condition, characterized by specific kidney deposits, did not respond to standard immunosuppressive therapy.

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Area of Science:

  • Nephrology
  • Rheumatology
  • Pathology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Nephrotic syndrome is a kidney disorder characterized by heavy protein loss in the urine.
  • Fibrillary glomerulonephritis (FGN) is a rare kidney disease.

Observation:

  • A 59-year-old male patient with a 10-year history of rheumatoid arthritis presented with nephrotic syndrome.
  • Renal biopsy revealed mesangial proliferation with fibrillary deposits (20 nm) on electron microscopy.
  • Congo-red stain was negative, ruling out amyloidosis.

Findings:

  • Laboratory results showed hypocomplementemia and lambda type Bence-Jones protein in urine.
  • The patient had no other systemic diseases, including multiple myeloma.

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  • Immunosuppressive therapy failed to reduce nephrotic-range proteinuria.

    • Implications:

    • This case highlights a rare presentation of fibrillary glomerulonephritis (FGN) in a patient with rheumatoid arthritis.
    • The co-occurrence of FGN and hypocomplementemia is unusual and presents diagnostic challenges.
    • The resistance to immunosuppressive therapy suggests alternative treatment strategies may be necessary for such cases.