Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-11 and its receptor.

Y C Yang1, T Yin

  • 1Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202.

Biofactors (Oxford, England)
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Genome-Wide Association Study for Female Fertility Traits in German Holstein Cattle.

Animal genetics·2026
Same author

Single-Step Breeding Value Estimations and Optimum Contribution Selection in Endangered Dual-Purpose German Black Pied Cattle (DSN) Using a Breed Specific SNP Chip.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2025
Same author

[Construction and verification of pancreatic fistula risk prediction model after pancreaticoduodenectomy based on ensemble machine learning].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2024
Same author

Effects of prenatal heat stress on birth weight and birth weight genetic parameters in German Holstein calves.

JDS communications·2023
Same author

[Apatinib Suppressed Macrophage-Mediated Malignant Behavior of Hepatocellular Carcinoma Cells via Modulation of VEGFR2/STAT3/PD-L1 Signaling].

Molekuliarnaia biologiia·2023
Same author

Direct genetic effects, maternal genetic effects, and maternal genetic sensitivity on prenatal heat stress for calf diseases and corresponding genomic loci in German Holsteins.

Journal of dairy science·2022
Same journal

Alpinia zerumbet-Derived Extracellular Vesicles Protect Against UVB-Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function.

BioFactors (Oxford, England)·2026
Same journal

Integrative Multi-Omics Analysis Reveals the Tumor-Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer.

BioFactors (Oxford, England)·2026
Same journal

Dauriporphine Inhibits the Proliferation, Migration, Angiogenesis, and Glycolysis in Lung Cancer Cells by Repressing PGK1 Expression via CEBPA.

BioFactors (Oxford, England)·2026
Same journal

An AI-Driven Multi-Omics Framework Identifies CASP8 as a Clinically Actionable Pyroptosis Biomarker in Bladder Cancer.

BioFactors (Oxford, England)·2026
Same journal

Targeting the Tumor Immune Ecosystem in Glioblastoma: Challenges and Innovations in Immunotherapy.

BioFactors (Oxford, England)·2026
Same journal

Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.

BioFactors (Oxford, England)·2026
See all related articles

Interleukin-11 (IL-11) is a cytokine involved in various biological processes. Research shows IL-11 shares signaling pathways with IL-6, utilizing the gp130 signal transducer.

Area of Science:

  • Cytokine biology
  • Molecular signaling
  • Cellular biology

Background:

  • Interleukin-11 (IL-11) is a cytokine with diverse biological activities, including support for specific cell growth and immune responses.
  • IL-11 influences megakaryocyte formation, acute phase protein synthesis, and adipocyte differentiation.
  • The human IL-11 gene is located at 19q13.3-13.4 and encodes a protein involved in receptor binding.

Purpose of the Study:

  • To compare the signal transduction pathways of Interleukin-6 (IL-6) and Interleukin-11 (IL-11) due to their overlapping biological functions.
  • To investigate the role of gp130 in IL-11 mediated signaling.

Main Methods:

  • Analysis of protein tyrosine phosphorylation in response to IL-6 and IL-11.
  • Examination of immediate early gene expression induced by IL-6 and IL-11.

Related Experiment Videos

  • Comparison of signaling pathways in cell lines responsive to both cytokines.

    • Main Results:

    • Protein tyrosine phosphorylation and gene expression patterns indicate both shared and distinct signaling mechanisms for IL-6 and IL-11.
    • The IL-6 signal transducer, gp130, is implicated in IL-11 signaling.
    • Other cytokines like leukemia inhibitory factor also utilize gp130.

    Conclusions:

    • IL-6 and IL-11 utilize convergent and divergent signal transduction pathways.
    • gp130 serves as a common signal transducer for multiple cytokines, including IL-11 and IL-6.
    • The study highlights the significance of shared signaling pathways among cytokines with similar biological activities.